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Injectable PT-141 (bremelanotide) is a prescription medication originally developed for treating sexual dysfunction. It works through central mechanisms in the brain (melanocortin receptor agonism) rather than through the vascular system, which differentiates it from drugs like sildenafil (Viagra).
FDA-approved for hypoactive sexual desire disorder (HSDD) in premenopausal women. Shown to improve desire and reduce distress associated with low libido.
Unlike drugs such as Viagra or Cialis, PT-141 doesn’t act on the vascular system directly. Instead, it stimulates the brain’s sexual desire pathways. This makes it potentially useful for individuals who don’t respond well to PDE5 inhibitors.
While FDA-approved for women, PT-141 is used off-label in men to enhance libido and potentially assist in erectile function, especially in cases with a psychological component.
Effects may begin within 30–60 minutes after injection.
Offers spontaneity compared to daily hormone therapy or oral medications requiring longer planning.
Since it doesn’t cause significant vasodilation like PDE5 inhibitors, it may be considered safer for some patients with cardiovascular conditions (under medical supervision).
May help individuals with sexual arousal disorders, not just desire dysfunction.
Acts centrally to initiate sexual arousal independent of tactile stimulation.
Administered subcutaneously, typically as-needed (not daily).

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